Fatal Familial Insomnia (FFI) – 1 to 2 People Per Million Annually

What is FFI?: Fatal familial insomnia (FFI) is a rare, fatal neurodegenerative prion disease caused by a misfolded PRNP gene, which creates toxic protein build-up, primarily in the thalamus. Characterized by severe insomnia, the disorder causes rapid physical and mental deterioration, including autonomic nervous system failure, hallucinations, and dementia. FFI currently has no cure. Symptoms:… Read.