Cold Agglutinin Disease (CAD) – 1 Person Per Million Annually

What is CAD?: CAD is a rare autoimmune hemolytic anemia where the immune system mistakenly “tags” red blood cells for destruction. This process is uniquely triggered by cold temperatures (typically 3-4 degrees Celsius), causing red blood cells to perish much faster than their normal 120-day lifespan. Primarily affecting adults between 40 and 80, the disorder… Read.